Structure of PDB 6khy Chain A

Receptor sequence
>6khyA (length=299) Species: 561443 (African swine fever virus tick/South Africa/Pretoriuskop Pr4/1996) [Search protein sequence]
GGGMFGAFVSHRLWSDSGCTTTCITNSIANYVAFGEQIGFPFKSAQVFIA
GPRKAVINIQEDDKVELLKMIVKHNLWVVAHGTYLDVPWSRRSAFVTHFI
QQELLICKEVGIKGLVLHLGAVEPELIVEGLKKIKPVEGVVIYLETPHNK
HHTYKYSTMEQIKELFLRIRNTRLKQIGLCIDTAHIWSSGVNISSYNDAG
QWLRSLENIHSVIPPSHIMFHLNDAATECGSGIDRHASLFEGMIWKSYSH
KIKQSGLYCFVEYITRHQCPAILERNLGSSMQLQTALTAEFTTLKSLLK
3D structure
PDB6khy A unique DNA-binding mode of African swine fever virus AP endonuclease.
ChainA
Resolution3.008 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y81 L82 V84 F92 G117 A118 N146 K147 Y84 L85 V87 F95 G120 A121 N149 K150
BS02 dna A R50 Y81 D231 R53 Y84 D234
BS03 ZN A H78 H115 E142 H81 H118 E145
BS04 ZN A E142 D179 H218 E271 E145 D182 H221 E274
BS05 ZN A H182 D231 H233 H185 D234 H236
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0008081 phosphoric diester hydrolase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6khy, PDBe:6khy, PDBj:6khy
PDBsum6khy
PubMed32194979
UniProtP0C9C6|APE_ASFP4 Probable AP endonuclease (Gene Name=Pret-146)

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