Structure of PDB 6kho Chain A

Receptor sequence
>6khoA (length=490) Species: 39947 (Oryza sativa Japonica Group) [Search protein sequence]
TFQPLNADDVRSYLHKAVDFISDYYKSVESMPVLPNVKPGYLQDELRASP
PTYSAPFDVTMKELRSSVVPGMTHWASPNFFAFFPSTNSAAAIAGDLIAS
AMNTVGFTWQASPAATEMEVLALDWLAQMLNLPTSFMNGRGTGGGVILGT
TSEAMLVTLVAARDAALRRSGSDGVAGLHRLAVYAADQTHSTFFKACRLA
GFDPANIRSIPTGAETDYGLDPARLLEAMQADADAGLVPTYVCATVGTTS
SNAVDPVGAVADVAARFAAWVHVDAAYAGSACICPEFRHHLDGVERVDSI
SMSPHKWLMTCLDCTCLYVRDTHRLTGSLETNPEYLKNHASDSGEVTDLK
DMQVGVGRRFRGLKLWMVMRTYGVAKLQEHIRSDVAMAKVFEDLVRGDDR
FEVVVPRNFALVCFRIRAGAGAAAATEEDADEANRELMERLNKTGKAYVA
HTVVGGRFVLRFAVGSSLQEEHHVRSAWELIKKTTTEMMN
3D structure
PDB6kho Crystal structure ofOryza sativaTDC reveals the substrate specificity for TDC-mediated melatonin biosynthesis.
ChainA
Resolution1.972 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.28: aromatic-L-amino-acid decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A F104 T174 T175 S176 H214 T273 D298 A300 K330 F84 T150 T151 S152 H190 T249 D274 A276 K306
BS02 PLP A V380 G381 V356 G357
Gene Ontology
Molecular Function
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0036467 5-hydroxy-L-tryptophan decarboxylase activity
GO:0036469 L-tryptophan decarboxylase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006587 serotonin biosynthetic process from tryptophan
GO:0019752 carboxylic acid metabolic process
GO:0042427 serotonin biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:6kho, PDBe:6kho, PDBj:6kho
PDBsum6kho
PubMed32595985
UniProtQ6ZJK7|TDC1_ORYSJ Tryptophan decarboxylase 1 (Gene Name=TDC1)

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