Structure of PDB 6khe Chain A

Receptor sequence
>6kheA (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
EDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALK
IIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISF
ELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKP
ENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVS
TRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMM
ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLT
SEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAE
3D structure
PDB6khe Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3NG A L169 G170 E171 V177 A191 K193 F243 E244 L245 L246 L297 V326 D327 L26 G27 E28 V34 A48 K50 F100 E101 L102 L103 L154 V183 D184 BindingDB: IC50=4.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0010212 response to ionizing radiation
GO:0016310 phosphorylation
GO:0043484 regulation of RNA splicing
GO:0045721 negative regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016604 nuclear body
GO:0016607 nuclear speck

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6khe, PDBe:6khe, PDBj:6khe
PDBsum6khe
PubMed31531359
UniProtP49760|CLK2_HUMAN Dual specificity protein kinase CLK2 (Gene Name=CLK2)

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