Structure of PDB 6kds Chain A

Receptor sequence
>6kdsA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMVINGEMQFYARAKLFYQEVPATEEGMMGNFIELSSPDIQASQKFLRK
FVGGPGRAGTDCALDCGSGIGRVSKHVLLPVFNSVELVDMMESFLLEAQN
YLQVKGDKVESYHCYSLQEFTPPFRRYDVIWIQWVSGHLTDKDLLAFLSR
CRDGLKENGIIILKDNVAREGCILDLSDSSVTRDMDILRSLIRKSGLVVL
GQEKQDGFPEQCIPVWMFALH
3D structure
PDB6kds Substrate engagement regulates state-specific alpha-N methylation of CENP-A by NRMT2
ChainA
Resolution1.844 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.299: protein N-terminal monomethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M87 F90 W191 N223 R226 Q268 C269 I270 M30 F33 W134 N166 R169 Q211 C212 I213
BS02 SAH A Y76 G124 G126 R129 D146 M147 F151 S173 L174 Q190 W191 V192 H195 Y19 G67 G69 R72 D89 M90 F94 S116 L117 Q133 W134 V135 H138
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0006480 N-terminal protein amino acid methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6kds, PDBe:6kds, PDBj:6kds
PDBsum6kds
PubMed
UniProtQ5VVY1|NTM1B_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 2 (Gene Name=NTMT2)

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