Structure of PDB 6kcl Chain A

Receptor sequence
>6kclA (length=533) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKE
VNVENYLLECNNIIVKNDEISYFYNLTVVVKTFVNDPLSMLVVIKYIEEL
MKRIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEEIINNMVDNI
EFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQ
YNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNVEPKRAVQRMFEMIN
EGASVIDIGGESKISERDLVVPVLQLFQKEWNDIKNKIVKCDAKPIISID
TINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLMHKR
GNPHTMDELTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAK
KHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMNDQLLYQKNICGGLAI
ASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQV
3D structure
PDB6kcl The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PE0 A D482 N502 I504 M529 D575 F580 G605 K609 R686 D350 N370 I372 M397 D443 F448 G473 K477 R513
BS02 ATP A K185 D208 D210 I211 N312 I313 E314 F315 L316 S317 H320 K145 D156 D158 I159 N199 I200 E201 F202 L203 S204 H207
BS03 MG A D208 D210 D156 D158
BS04 CA A E42 G46 E99 E38 G42 E73
Gene Ontology
Molecular Function
GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156 dihydropteroate synthase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0016310 phosphorylation
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005740 mitochondrial envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kcl, PDBe:6kcl, PDBj:6kcl
PDBsum6kcl
PubMed31883412
UniProtQ25704

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