Structure of PDB 6kck Chain A

Receptor sequence
>6kckA (length=551) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKE
VNVENYLLECNNIIVKNDEISYFYNLTVVVKTFVNDPLSMLVVIKYIEEL
MKRRIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEDPQEIINNM
VDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSR
MKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNFVEPKRAVQRM
FEMINEGASVIDIGGESSAPFVIPNPKISERDLVVPVLQLFQKEWNDIKN
KIVKCDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLK
KKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIP
RYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMND
KDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVK
D
3D structure
PDB6kck The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PE0 A D482 N502 M529 D575 G605 K609 R686 D364 N384 M411 D457 G487 K491 R529
BS02 APC A K185 R205 D208 D210 I211 N312 I313 E314 F315 L316 S317 H320 Y322 R326 K145 R154 D157 D159 I160 N203 I204 E205 F206 L207 S208 H211 Y213 R217
BS03 MG A D208 D210 D157 D159
BS04 CA A E42 G46 E99 E38 G42 E73
Gene Ontology
Molecular Function
GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156 dihydropteroate synthase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0016310 phosphorylation
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005740 mitochondrial envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kck, PDBe:6kck, PDBj:6kck
PDBsum6kck
PubMed31883412
UniProtQ25704

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