Structure of PDB 6kbw Chain A

Receptor sequence

>6kbwA (length=446) Species: 480520 (Myroides profundi) [Search protein sequence]

MLNLKVGIIGAGPSGLAMLRAFESEQKKGNPIPEIKCYEKQDNWGGMWNY
TWRTGVGKYGEPIHGSMYKYLWSNGPKECLEFSDYTFMEHFKQPISSYPP
REVLFDYIQGRIKQSNARDFIKFNTVARWVDYLEDKKQFRVIFDDLVKNE
TFEEYFDYLVVGTGHFSTPNMPYFKGIDSFPGTVMHAHDFRGADQFIDKD
ILLIGSSYSAEDIGVQCFKHGSKSVTISYRTNPIGAKWPKGIEEKPIVTH
FEDNVAHFKDGSKKEYDAVILCTGYQHKFPFLPDNLRLKTKNNLYPDNLY
KGVVFNENERLIFLGMQDQYYTFNMFDTQAWFARDYMLGRIALPNKEIRD
KDIAKWVELEKTSVTGEEHVDFQTDYIKELIEMTDYPTFDLDRVAEMFKS
WLNDKETNILNYRDKVYTSVMTGVTAEEHHTPWMKELDDSLERYLD

3D structure

PDB

6kbw Oxidation of trimethylamine to trimethylamine N-oxide facilitates high hydrostatic pressure tolerance in a generalist bacterial lineage.

Chain

Resolution

1.686 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.148: trimethylamine monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	W72 N74 F166 S206 S207 Y208 S209 D212 R230 C272 T273	W72 N74 F166 S206 S207 Y208 S209 D212 R230 C272 T273
BS02	FAD	A	I9 G12 P13 S14 E39 K40 Q41 G46 M47 W48 H64 M67 S73 N74 V126 A127 G162 T163 Q319 T322 F326	I9 G12 P13 S14 E39 K40 Q41 G46 M47 W48 H64 M67 S73 N74 V126 A127 G162 T163 Q319 T322 F326

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

View graph for
Molecular Function

External links

PDB	RCSB:6kbw, PDBe:6kbw, PDBj:6kbw
PDBsum	6kbw
PubMed	33771875
UniProt	A0A0B5RNJ4\|TMM_MYRPR Trimethylamine monooxygenase (Gene Name=Mptmm)

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