Structure of PDB 6kbd Chain A

Receptor sequence

>6kbdA (length=616) Species: 83332,523850 [Search protein sequence]

IDELTALGGLLHDIGKPVQRAGLDHSTQGARFLRDLAENTGRAEYELLSL
FSEFLMIRRIKELSPERFGLTMEDVLNALWIVYEADNLASSRPLYSVFNP
GKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKRLWEELSKAKLRSDRL
LPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRAGCTAEDVRSG
RCRKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVL
EILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAVEWLYREF
ESDLYLAIEWEPVSGREFGRENLFAEARKRLKHKLTVRKLKCPTCNRLVS
LGGNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGGRPVGEQILVKNTL
NPGEIPESAQFVPYFVADYFKKARLGVLRLDVDNLGQAFTHGFNTISRTA
AFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYSGGDDVFVV
GAWDDVIEFGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDL
EDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYAFIYKLLELLPTDA
KQLKTALHLYIYRTRK

3D structure

PDB

6kbd Mycobacterium tuberculosis CRISPR/Cas system Csm1 holds clues to the evolutionary relationship between DNA polymerase and cyclase activity.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.-
3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DTP	A	F240 S241 G242 I243 I247 S263 L266 Y623 D628	F215 S216 G217 I218 I222 S238 L241 Y491 D496
BS02	DTP	A	F290 A292 D555 V556 N558 L559 G560 F563 S585 G626 D627 K687 K692	F265 A267 D431 V432 N434 L435 G436 F439 S453 G494 D495 K555 K560
BS03	MG	A	D555 V556 D557	D431 V432 D433
BS04	MG	A	D555 D627 D628	D431 D495 D496

External links

PDB	RCSB:6kbd, PDBe:6kbd, PDBj:6kbd
PDBsum	6kbd
PubMed	33352158
UniProt	B6YWB8\|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1); P71629

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