Structure of PDB 6kba Chain A

Receptor sequence
>6kbaA (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKSLAKRIYEAYLKNFNMNKVKARVILSGSNNPPFVIHDMETLCMAEKT
LVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLN
DQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCD
IMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEG
IVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESD
AALHPLLQEIYRDMY
3D structure
PDB6kba PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WY1 A L247 E251 V255 L258 I263 K266 R271 I272 H274 C275 C278 L44 E48 V52 L55 I60 K63 R68 I69 H71 C72 C75 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
BS02 WY1 A C276 T279 S280 Y314 L321 M330 M355 K358 H440 Y464 C73 T76 S77 Y111 L118 M127 M152 K155 H237 Y261 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6kba, PDBe:6kba, PDBj:6kba
PDBsum6kba
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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