Structure of PDB 6kb8 Chain A

Receptor sequence
>6kb8A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
MTADLKSLAKRIYEAYLKNFNMNKVKARVILSGPFVIHDMETLCMAEKTL
VAKLVQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL
LKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPK
FDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVL
RLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHP
LLQEIYRDMY
3D structure
PDB6kb8 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOL A K222 R226 S323 M325 N366 K24 R28 S115 M117 N158
BS02 2VN A F273 C276 Q277 T279 S280 T283 Y314 H440 Y464 F65 C68 Q69 T71 S72 T75 Y106 H232 Y256 BindingDB: EC50=200nM,Kd=1.000000nM,IC50=0.46nM,Ki=0.054100nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kb8, PDBe:6kb8, PDBj:6kb8
PDBsum6kb8
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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