Structure of PDB 6kb7 Chain A

Receptor sequence
>6kb7A (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKSLAKRIYEAYLKNFNMNKVKARVILSGNNPPFVIHDMETLCMAEKTL
VAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLND
QVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDI
MEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGI
VHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDA
ALHPLLQEIYRDMY
3D structure
PDB6kb7 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WY1 A C276 T279 S280 Y314 L321 M355 K358 H440 Y464 C72 T75 S76 Y110 L117 M151 K154 H236 Y260 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
BS02 WY1 A L247 E251 L258 I263 K266 R271 H274 C275 C278 L43 E47 L54 I59 K62 R67 H70 C71 C74 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kb7, PDBe:6kb7, PDBj:6kb7
PDBsum6kb7
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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