Structure of PDB 6kb4 Chain A

Receptor sequence
>6kb4A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
MTADLKSLAKRIYEAYLKNFNMNKVKARVILSGSNNPPFVIHDMETLCMA
EKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKP
FCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKM
QEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKT
ESDAALHPLLQEIYRDMY
3D structure
PDB6kb4 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution1.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOL A K222 R226 S323 M325 N326 N366 K24 R28 S123 M125 N126 N166
BS02 P7F A F273 C275 C276 T279 S280 Y314 I317 F318 M320 L321 V332 M355 H440 F73 C75 C76 T79 S80 Y114 I117 F118 M120 L121 V132 M155 H240 BindingDB: EC50=1nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kb4, PDBe:6kb4, PDBj:6kb4
PDBsum6kb4
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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