Structure of PDB 6kb2 Chain A

Receptor sequence
>6kb2A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE
KTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD
LNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPF
CDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQ
EGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTE
SDAALHPLLQEIYRDMY
3D structure
PDB6kb2 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WY1 A C276 T279 S280 Y314 L321 M355 K358 H440 Y464 C75 T78 S79 Y113 L120 M154 K157 H239 Y263 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
BS02 WY1 A L247 E251 V255 L258 I263 K266 R271 I272 H274 C275 C278 L46 E50 V54 L57 I62 K65 R70 I71 H73 C74 C77 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kb2, PDBe:6kb2, PDBj:6kb2
PDBsum6kb2
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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