Structure of PDB 6kaz Chain A

Receptor sequence
>6kazA (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKSLAKRIYEAYLKNFNMNKVKARVILSGPPFVIHDMETLCMAEKTLVA
KLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQV
TLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVH
VLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAAL
HPLLQEIYRDMY
3D structure
PDB6kaz PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOL A K222 R226 S323 M325 N326 N366 K21 R25 S117 M119 N120 N160
BS02 P7F A F273 C275 C276 T279 S280 Y314 I317 F318 M320 L321 V332 M355 H440 F67 C69 C70 T73 S74 Y108 I111 F112 M114 L115 V126 M149 H234 BindingDB: EC50=1nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kaz, PDBe:6kaz, PDBj:6kaz
PDBsum6kaz
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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