Structure of PDB 6k90 Chain A

Receptor sequence
>6k90A (length=295) Species: 981087 (Leishmania donovani BPK282A1) [Search protein sequence]
DKHVLSIQSHVTHGYVGNKAATFPLQLHGFDVDAINTVSLSNHSGYPVIK
GHRMDLEEFTTIMEGLRANDFLSDYAYVLTGYINNRDIVRQVAATVAEIR
EARQKQGKKDAVFFCDPVMGDDGRLYCKEEVVEAYRELLTHADVATPNYF
EASILSTVEVKDLASAIEAANWFHTQGTPTVVIKSFADDPTHLRFLLSCR
DTGSTKRYTGVVPYHEGRYTGTGDVFAASLVAFAHSDPMDLAVGKAMGVL
QDLIKATIERGGSGKATLSSRELRVTSYPDRLQHPSSVALVTPLP
3D structure
PDB6k90 Structural attributes and substrate specificity of pyridoxal kinase from Leishmania donovani.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.35: pyridoxal kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PXM A S12 V19 H46 S47 Y85 Y129 S9 V16 H43 S44 Y82 Y126
BS02 ADP A D124 N151 K187 S188 L198 H222 T229 G230 M254 L257 Q258 I261 D121 N148 K184 S185 L193 H215 T222 G223 M247 L250 Q251 I254
BS03 CA A D124 Y226 D121 Y219
BS04 CA A T143 G180 T140 G177
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008478 pyridoxal kinase activity
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009443 pyridoxal 5'-phosphate salvage
GO:0016310 phosphorylation
GO:0042816 vitamin B6 metabolic process
Cellular Component
GO:0005829 cytosol

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External links
PDB RCSB:6k90, PDBe:6k90, PDBj:6k90
PDBsum6k90
PubMed32105687
UniProtA0A3S7X3C0

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