Structure of PDB 6k7r Chain A

Receptor sequence
>6k7rA (length=275) Species: 6689 (Penaeus vannamei) [Search protein sequence]
RHDEYQYLDLIRQIMRTGNRKGGTISMFGAQMRYSLRDGIFPLLTTKRVF
WRGVAEELLWFVRGSTNAKELQEKDIHIWDGNSSKEFLNKMGFHDREEGD
LGPVYGFQWRHFGAPYADMHTDYTGQGVDQLQQVIDTIKNNPDDRRIIMC
AWNPVDVPKMALPPCHCLCQFYVANGELSCQLYQRSADMGLGVPFNIASY
ALLTYMIAHVTDLKPGDFVHTLGDAHVYSNHCEALEEQLKREPRPFPSLK
IKRKVENISDFKFEDFELDGYKPHP
3D structure
PDB6k7r Structural analysis of a shrimp thymidylate synthase reveals species-specific interactions with dUMP and raltitrexed.
ChainA
Resolution1.54 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E63 W85 Y111 C171 R191 D194
Catalytic site (residue number reindexed from 1) E57 W79 Y105 C165 R185 D188
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP A C171 R191 S192 D194 N202 H232 Y234 C165 R185 S186 D188 N196 H226 Y228
BS02 UMP A R151 R152 R145 R146
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6k7r, PDBe:6k7r, PDBj:6k7r
PDBsum6k7r
PubMed
UniProtA0A423U5Z1

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