Structure of PDB 6k7l Chain A

Receptor sequence
>6k7lA (length=992) Species: 9606 (Homo sapiens) [Search protein sequence]
EVRTIFINQPAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPT
GRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIV
HWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCYIETSNLDGETNLKI
RQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRVPLGADQILL
RGAQLRNTQWVHGIVVYTGHTSPPLKLSNVERITNVQILILFCILIAMSL
VCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLL
VTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDK
TGTLTCNVMQFKKCTIAGVAYGQFSDSSLLENLQNNHPTAPIICEFLTMM
AVCHTAVPERERDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDS
LGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAE
TSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQ
NRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWIL
TGDKQETAINIGHSCKLLKKNMGMIVINDFALIIDGKTLKYALTFGVRQY
FLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQ
TAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCIL
YCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGI
FERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPL
KALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIA
IWGSIALWVVFFGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPV
ASLLLDVVYKVIKRTAFKLHGYAFSQDENGIVSQSEVIRAYD
3D structure
PDB6k7l Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
ChainA
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BEF A G190 D409 K410 T411 G671 K766 N789 G144 D349 K350 T351 G602 K671 N694
BS02 MG A D409 T411 D786 D349 T351 D691
BS03 Y01 A W942 A1046 L1050 W847 A951 L955
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0046872 metal ion binding
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity
Biological Process
GO:0006869 lipid transport
GO:0007612 learning
GO:0015914 phospholipid transport
GO:0030335 positive regulation of cell migration
GO:0034220 monoatomic ion transmembrane transport
GO:0045332 phospholipid translocation
GO:0048488 synaptic vesicle endocytosis
GO:0061092 positive regulation of phospholipid translocation
GO:0098655 monoatomic cation transmembrane transport
GO:0140331 aminophospholipid translocation
GO:0150104 transport across blood-brain barrier
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030672 synaptic vesicle membrane
GO:0031090 organelle membrane
GO:0031410 cytoplasmic vesicle
GO:0035577 azurophil granule membrane
GO:0035579 specific granule membrane
GO:0042584 chromaffin granule membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098978 glutamatergic synapse
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k7l, PDBe:6k7l, PDBj:6k7l
PDBsum6k7l
PubMed31416931
UniProtQ9Y2Q0|AT8A1_HUMAN Phospholipid-transporting ATPase IA (Gene Name=ATP8A1)

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