Structure of PDB 6k5l Chain A

Receptor sequence
>6k5lA (length=565) Species: 1045010 (Escherichia coli O157) [Search protein sequence]
MPRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNR
IHLYDHHVGLVVEQLRCITNGQSTDAEFLLRVKEHYTRLLPDYPRFEIAE
SFFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFHPDHGWE
SLLMRVISDLPLRLHWQNKSRDIHYIIRHLTETLGPENLSKSHLQVANEL
FYRNKAAWLVGKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEASIVF
GFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYRE
YLVYLQGCNEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDKFAPQKEMSA
AHVRACYQLVKEHDRVGRMADTQEFENFVLEKRHISPALMELLLQEAAEK
ITDLGEQIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAA
ANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRPWYSVS
PGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQNRIREGHVED
VYAYRRRQRFSVRYG
3D structure
PDB6k5l Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.5: [isocitrate dehydrogenase (NADP(+))] kinase.
3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A N104 S105 H113 L116 K291 K294 T295 Y298 F375 N377 N104 S105 H113 L116 K291 K294 T295 Y298 F375 N377
BS02 ADP A I318 G320 V322 M323 V325 V334 K336 M419 Y474 D475 I318 G320 V322 M323 V325 V334 K336 M419 Y474 D475
BS03 MN A N462 D475 N462 D475
BS04 MN A D475 D477 D475 D477
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008772 [isocitrate dehydrogenase (NADP+)] kinase activity
GO:0016208 AMP binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016791 phosphatase activity
GO:0030145 manganese ion binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k5l, PDBe:6k5l, PDBj:6k5l
PDBsum6k5l
PubMed31235769
UniProtP11071|ACEK_ECOLI Isocitrate dehydrogenase kinase/phosphatase (Gene Name=aceK)

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