Structure of PDB 6k4t Chain A

Receptor sequence
>6k4tA (length=260) Species: 615 (Serratia marcescens) [Search protein sequence]
RDWSSPQQPFTIYGNTHYVGTGGISAVLLSSPQGHILVDGTTEKGAQVVA
ANIRAMGFKLSDVKYILSTHSHEDHAGGISAMQKLTGATVLAGAANVDTL
RTGVSPKSDPQFGSLSNFPGSAKVRAVADGELVKLGPLAVKAHATPGHTE
GGITWTWQSCEQGKCKDVVFADSLTAVSADSYRFSDHPEVVASLRGSFEA
VEKLSCDIAIAAHPEVNDMWTRQQRAAKEGNSAYVDNGACRAIAAAGRKR
LETRLASEKR
3D structure
PDB6k4t 4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-beta-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-beta-Lactamase Subclasses.
ChainA
Resolution1.39 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H72 H74 D76 H77 H150 Y184 H215
Catalytic site (residue number reindexed from 1) H70 H72 D74 H75 H148 Y182 H213
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H72 H74 H150 H70 H72 H148
BS02 ZN A D76 H77 H215 D74 H75 H213
BS03 JKE A H72 D76 H77 H150 S175 T177 V179 H215 H70 D74 H75 H148 S173 T175 V177 H213 PDBbind-CN: -logKd/Ki=6.02,IC50=0.95uM
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0046872 metal ion binding
Biological Process
GO:0030655 beta-lactam antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6k4t, PDBe:6k4t, PDBj:6k4t
PDBsum6k4t
PubMed31405855
UniProtG5ELM3

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