Structure of PDB 6k32 Chain A

Receptor sequence

>6k32A (length=1208) Species: 205895 (Cypovirus 1)

TKLHNTIFSETRKFTRESFKEIEHLTARLANDRVARHDFLFNTSIVLISD
YSGEDSNGNQLQATITIPNEIINPKEYDPSDYPLAEDESFFKQGHKYDYL
VTFRAGSLTNTYEPKTKMYKLHAALDKLMHVKQRKSRFADLWRELCAVIA
SLDVWYQTTNYPLRTYVKLLFHKGDEFPFYESPSQDRIIFNDKSVASILP
TFVYTCCQVGTAIMSGILTHVESIVAMNHFLHCAKDSYIDEKLKIKGIGR
SWYQEALHNVCQATVPVWSQFNEVIGHRTKSTSEPHFVSSTFISLRAKRA
ELLYPEFNAYINRAIQLSKTQNDVANYYAACRAMTNDGTFLATLTELSLD
AAVFPRIEQHLVTRPAVLMSNTRHESLKQKYTNGVGSIAQSYLSSFTDEI
AKRVNGRHHDEAWLNFLTTSSPGRKLTEIEKLEVGGDVAAWSNSRIVMQA
VFAREYRTPERIFKSLKAPIKLVERQQSDRRQRAISGLDNDRLFLSFMPY
TIGKQIYELNDNAAQGKQAGNAFDIGEMLYWTSQRNVLLSSIDVAGMDAS
VTTNTKDIYNTFVLDVASKCTVPRFGPYYAKNMEVFEAGNRQSQVRYVNA
AWQACALEAANSQTSTSYESEIFGQVKNAEGTYPSGRADTSTHHTVLLQG
LVRGNELKRASDGKNSCLATIKILGDDIMEIFQGSESDTYDHAVSNASIL
NESGFATTAELSQNSIVLLQQLVVNGTFWGFADRISLWTREDTKDIGRLN
LAMMELNALIDDLVFRVRRPEGLKMLGFFCGAICLRRFTLSVDNKLYDST
YNNLSKYMTLTKYDKNPDSDSTLMSLILPLAWLFMPRGGEYPAYPFERRD
GTFTEDESMFTARGAYKRRLLYDVSNIGEMIQQNSMALDDDLLHEYGFTG
ALLLIDLNILDLIDEVKKEDISPVKVSELATSLEQLGKLGEREKSRRAAS
DLKIRGHALSNDIVYGYGLQEKIQKSAMATKETTVQSKRVSSRLHDVIVA
KTRDYKISTIPADALHLHEFEVEDVTVDLLPHAKHTSYSSLAYNMSFGSD
GWFAFALLGGLDRSANLLRLDVASIRGNYHKFSYDDPVFKQGYKIYKSDA
TLLNDFFTAISAGPKEQGILLRAFAYYSLYGNVEYHYVLSPRQLFFLSDN
PVSAERLVRIPPKYYVSTQCRALYNIFSYLHILRSIANNRGKRLKMVLHP
GLIAYVRG

3D structure

• PDB: 6k32 Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis.
• Chain: A
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	F420 S425 P426 R449 V477 I489 G491 Y504 S639 G640 S645 D746 T747 Y1083	F416 S421 P422 R445 V473 I485 G487 Y500 S635 G636 S641 D742 T743 Y1079
BS02	rna	A	L678 G679 D681 L723 Q724 R738 I739 H1084 K1085 R1146	L674 G675 D677 L719 Q720 R734 I735 H1080 K1081 R1142
BS03	MG	A	D547 V548 D680	D543 V544 D676
BS04	MG7	A	R37 Y184 S186 S188	R33 Y180 S182 S184
BS05	A2M	A	T793 S795	T789 S791
BS06	UTP	A	R484 R487 V548 A549 G550 M551 T644 H648 D680	R480 R483 V544 A545 G546 M547 T640 H644 D676

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0019079 viral genome replication

External links

• PDB: RCSB:6k32, PDBe:6k32, PDBj:6k32
• PDBsum: 6k32
• PubMed: 31629769
• UniProt: D0EZK6