Structure of PDB 6k1q Chain A

Receptor sequence
>6k1qA (length=410) Species: 9606,10665 [Search protein sequence]
QGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLYIIYKNKCMRNGPNILI
ASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVL
SLCALSIDRYRAVASWSVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMD
YKGSYLRICLLHPVQKTAFMQFYATAKDWWLFSFYFCLPLAITAFFYTLM
TCEMLRKNIFEMLRIDEGAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAV
RRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPN
RAKRVITTFRTGTWDAYLNDHLKQRREVAKTVFCLVLVFALCWLPLHLAR
ILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCANPIALYLVSKRF
KNAFKSALCC
3D structure
PDB6k1q Crystal structure of human endothelin ETBreceptor in complex with peptide inverse agonist IRL2500.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D2U A D147 H150 N158 K161 P178 Q181 K182 S184 V185 F240 Y281 W336 L339 R343 A375 S376 S379 D57 H60 N68 K71 P88 Q91 K92 S94 V95 F144 Y185 W343 L346 R350 A382 S383 S386 PDBbind-CN: -logKd/Ki=7.46,IC50=35nM
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0016998 cell wall macromolecule catabolic process
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6k1q, PDBe:6k1q, PDBj:6k1q
PDBsum6k1q
PubMed31263780
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P24530|EDNRB_HUMAN Endothelin receptor type B (Gene Name=EDNRB)

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