Structure of PDB 6k1e Chain A

Receptor sequence
>6k1eA (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
AKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLESPLSLLQMASP
SGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDY
GLVVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLLRCSNWDAET
LTEDQVIYAARDAQISVALFLHLLGYSSWRKVLEKCQGVVDIPFRS
3D structure
PDB6k1e The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.1: exodeoxyribonuclease I.
3.1.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D108 E110 D32 E34
BS02 MG A Y242 D246 Y158 D162
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6k1e, PDBe:6k1e, PDBj:6k1e
PDBsum6k1e
PubMed31127291
UniProtQ9NVH0|EXD2_HUMAN Exonuclease 3'-5' domain-containing protein 2 (Gene Name=EXD2)

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