Structure of PDB 6k05 Chain A

Receptor sequence
>6k05A (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGT
IKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQ
KVASMPQE
3D structure
PDB6k05 Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.
ChainA
Resolution1.935 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CQF A W97 P98 F99 K107 L108 L110 N156 W22 P23 F24 K32 L33 L35 N81 MOAD: Ki=95.5nM
PDBbind-CN: -logKd/Ki=6.56,Ki=275nM
BindingDB: Ki=9.1nM,Kd=45nM
External links
PDB RCSB:6k05, PDBe:6k05, PDBj:6k05
PDBsum6k05
PubMed31461688
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

[Back to BioLiP]