Structure of PDB 6k04 Chain A

Receptor sequence
>6k04A (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDL
STVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVF
EFRYAKMP
3D structure
PDB6k04 Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.
ChainA
Resolution1.251 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CQF A W370 P371 F372 V376 L383 N429 H433 V435 M438 W24 P25 F26 V30 L37 N83 H87 V89 M92 MOAD: Ki=3.1nM
PDBbind-CN: -logKd/Ki=8.04,Ki=9.1nM
BindingDB: Ki=9.1nM,Kd=45nM
External links
PDB RCSB:6k04, PDBe:6k04, PDBj:6k04
PDBsum6k04
PubMed31461688
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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