Structure of PDB 6jze Chain A

Receptor sequence
>6jzeA (length=254) Species: 10090 (Mus musculus) [Search protein sequence]
LFHVNKSGFPIDSHTWERMWLHVAKVHPRGGEMVGAIRNAAFLAKPSIPQ
VPNYRLSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAK
EMTRESLPIKCLEAVILGIYLTNGQPSIERFPISFKTYFSGNYFHHVVLG
IYCNGYYGSLGMSRRAELMDKPLTFRTLSDLVFDFEDSYKKYLHTVKKVK
IGLYVPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMRMKILKP
ASAH
3D structure
PDB6jze Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer.
ChainA
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.17.17: tubulinyl-Tyr carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I3C A K135 S181 F182 H192 H193 K247 K265 K88 S134 F135 H145 H146 K200 K218
BS02 I3C A A91 P93 Q122 A44 P46 Q75
BS03 I3C A S60 W63 S13 W16
Gene Ontology
Biological Process
GO:0045765 regulation of angiogenesis
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:6jze, PDBe:6jze, PDBj:6jze
PDBsum6jze
PubMed31324789
UniProtQ8C5G2|VASH2_MOUSE Tubulinyl-Tyr carboxypeptidase 2 (Gene Name=Vash2)

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