Structure of PDB 6jwy Chain A

Receptor sequence

>6jwyA (length=538) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

ELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLY
ETVPEYIVVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSI
LKEVNVENYLLECNNIIVKNDEIMKNNSYFYNLTVVVKTFVNDPLSMLVV
IKYIEELMKRRIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEPQ
EIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLY
NKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNYVEPK
RAVQRMFEMINEGASVIDIGGISERDLVVPVLQLFQKEWNDIKCDAKPII
SIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLM
HKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLG
FAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMNDQLLYQKNICGG
LAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKD

3D structure

PDB

6jwy The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.5 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CKL	A	D482 N502 I504 M529 D575 F580 F603 G605 K609 R610 R686	D353 N373 I375 M400 D446 F451 F474 G476 K480 R481 R516
BS02	PH2	A	T57 E60 Y61 F163 N165 R326 S328	T52 E55 Y56 F130 N132 R223 S225
BS03	ATP	A	K185 D208 I211 N312 F315 L316 S317 H320	K152 D164 I167 N209 F212 L213 S214 H217
BS04	MG	A	E188 D208	E155 D164
BS05	MG	A	D208 D210	D164 D166
BS06	CA	A	E42 G46 E99	E37 G41 E76

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6jwy, PDBe:6jwy, PDBj:6jwy
PDBsum	6jwy
PubMed	31883412
UniProt	Q25704

[Back to BioLiP]