Structure of PDB 6jwx Chain A

Receptor sequence

>6jwxA (length=544) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

IQELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSY
LYETVPEYIVVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDN
SILKEVNVENYLLECNNIIVKNDEIMKNNTSYFYNLTVVVKTFVNDPLSM
LVVIKYIEELMKRIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLE
IINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYN
KYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNYVEPKR
AVQRMFEMINEGASVIDIGGESKISERDLVVPVLQLFQKEWNDIKNKIVK
CDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNK
FYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRI
LFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMNDQLLY
QKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVK

3D structure

PDB

6jwx The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.5 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CKL	A	D482 N502 M529 D575 F580 G605 K609 R610 R686	D360 N380 M407 D453 F458 G483 K487 R488 R523
BS02	PH2	A	T57 V58 P59 E60 Y61 F163 N165 D208 R326	T54 V55 P56 E57 Y58 F133 N135 D166 R222
BS03	AMP	A	L181 D210 I211 N312 E314 F315 L316 S317 H320	L151 D168 I169 N208 E210 F211 L212 S213 H216
BS04	MG	A	D208 D210	D166 D168
BS05	CA	A	E42 G46 E99	E39 G43 E78

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6jwx, PDBe:6jwx, PDBj:6jwx
PDBsum	6jwx
PubMed	31883412
UniProt	Q25704

[Back to BioLiP]