Structure of PDB 6jww Chain A

Receptor sequence

>6jwwA (length=544) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPEYIVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSI
LKEVNVENYLLECNNIIVKNDTSYFYNLTVVVKTFVNDPLSMLVVIKYIE
ELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEQEIINNMVD
NIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMK
EQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNFVEPKRAVQRMFE
MINEGASVIDIGGESFGPKISERDLVVPVLQLFQKEWNDIKNKIVKCDAK
PIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSV
VLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDI
GLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFITHCMNDDKDQLLYQ
KNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKD

3D structure

PDB

6jww The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.75 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	XTZ	A	F436 G437 D482 N502 M529 D539 D575 F580 G605 K609 R610 R686	F316 G317 D356 N376 M403 D413 D449 F454 G479 K483 R484 R522
BS02	PH2	A	V58 E60 Y61 F163 N165 R326	V54 E56 Y57 F125 N127 R215
BS03	ATP	A	D208 D210 I211 N312 I313 F315 L316 S317 H320	D157 D159 I160 N201 I202 F204 L205 S206 H209
BS04	MG	A	D208 D210	D157 D159
BS05	CA	A	E42 G46 K47 E99	E38 G42 K43 E76

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6jww, PDBe:6jww, PDBj:6jww
PDBsum	6jww
PubMed	31883412
UniProt	Q25704

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