Structure of PDB 6jwv Chain A

Receptor sequence

>6jwvA (length=543) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPEYIVLDVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVD
NSILKEVNVENYLLECNNIIVKNDEIMKNNYTSYFYNLTVVVKTFVNDPL
SMLVVIKYIEELMKRIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIH
LEQEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIR
CLYNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNVE
PKRAVQRMFEMINEGASVIDIGGEKISERDLVVPVLQLFQKEWNDIDAKP
IISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVV
LMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIG
LGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMNDDKDQLLYQK
NICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKD

3D structure

PDB

6jwv The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	XTZ	A	D482 N502 M529 D575 F580 F603 G605 K609 R610 R686	D355 N375 M402 D448 F453 F476 G478 K482 R483 R521
BS02	PH2	A	T57 V58 E60 Y61 F163 N165 R326 S328	T53 V54 E56 Y57 F135 N137 R226 S228
BS03	ATP	A	L181 K185 R205 D208 D210 I211 N312 I313 F315 L316 S317 H320 Y322	L153 K157 R165 D168 D170 I171 N212 I213 F215 L216 S217 H220 Y222
BS04	MG	A	D208 D210	D168 D170
BS05	CA	A	E42 G46 E99	E38 G42 E79

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6jwv, PDBe:6jwv, PDBj:6jwv
PDBsum	6jwv
PubMed	31883412
UniProt	Q25704

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