Structure of PDB 6jwu Chain A

Receptor sequence

>6jwuA (length=558) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

ETIQELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINT
SYLYETVPEYIVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVD
NSILKEVNVENYLLECNNIIVKNDEIMKNSYFYNLTVVVKTFVNDPLSML
VVIKYIEELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEDP
QEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCL
YNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNGIFV
EPKRAVQRMFEMINEGASVIDIGGESSAPFVIPNPKISERDLVVPVLQLF
QKEWNDIIVKCDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPE
IIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFL
VLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFI
AHCMNDDKDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVL
TKIDQVKD

3D structure

PDB

6jwu The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.65 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	XTZ	A	S436 P438 D482 N502 I504 M529 D539 D575 G579 F580 G605 K609 R610 R686	S327 P329 D370 N390 I392 M417 D427 D463 G467 F468 G493 K497 R498 R536
BS02	PH2	A	Y61 F163 N165 D208 R326	Y60 F132 N134 D164 R224
BS03	AMP	A	L181 D208 D210 I211 N312 E314 F315 L316 S317 H320	L150 D164 D166 I167 N210 E212 F213 L214 S215 H218
BS04	MG	A	D208 D210	D164 D166
BS05	CA	A	E42 G46 E99	E41 G45 E79

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6jwu, PDBe:6jwu, PDBj:6jwu
PDBsum	6jwu
PubMed	31883412
UniProt	Q25704

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