Structure of PDB 6jwt Chain A

Receptor sequence

>6jwtA (length=548) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

LILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLYE
TVPVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVN
VENYLLECNNIIVKNDESYFYNLTVVVKTFVNDPLSMLVVIKYIEELMKI
IDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLERFRDPQEIINNMVD
NIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMK
EQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNVEPKRAVQRMFEM
INEGASVIDIGGESFGPFVIPNPKISERDLVVPVLQLFQKEWNDIKNKIV
KCDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKN
KFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYR
ILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFITHCMNDKDQ
LLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKD

3D structure

PDB

6jwt The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.56 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AMP	A	L181 D210 I211 N312 F315 L316 S317 H320	L138 D154 I155 N201 F204 L205 S206 H209
BS02	MG	A	D208 D210	D152 D154
BS03	PT1	A	G437 P438 D482 N502 I504 M529 D575 G579 F580 G605 K609 R610 R686	G316 P317 D361 N381 I383 M408 D454 G458 F459 G484 K488 R489 R526
BS04	CA	A	E42 G46 K47 E99	E36 G40 K41 E71

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6jwt, PDBe:6jwt, PDBj:6jwt
PDBsum	6jwt
PubMed	31883412
UniProt	Q25704

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