Structure of PDB 6jws Chain A

Receptor sequence

>6jwsA (length=551) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKE
VNVENYLLECNNIIVKNDEIMKSYFYNLTVVVKTFVNDPLSMLVVIKYIE
ELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEDPQEIINNM
VDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSR
MKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNVEPKRAVQRMF
EMINEGASVIDIGGESSGPFVIPNPKISERDLVVPVLQLFQKEWNDIKNK
IVKCDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKK
KNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPR
YRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMNDD
KDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVK
D

3D structure

PDB

6jws The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	PT1	A	S436 G437 P438 D482 N502 I504 M529 D575 F580 G605 K609 R610 R686	S317 G318 P319 D363 N383 I385 M410 D456 F461 G486 K490 R491 R529
BS02	ATP	A	K185 D208 D210 I211 N312 I313 E314 F315 L316 S317 H320	K147 D157 D159 I160 N203 I204 E205 F206 L207 S208 H211
BS03	MG	A	D208 D210	D157 D159
BS04	CA	A	E42 G46 E99	E38 G42 E73

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6jws, PDBe:6jws, PDBj:6jws
PDBsum	6jws
PubMed	31883412
UniProt	Q25704

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