Structure of PDB 6jwr Chain A

Receptor sequence

>6jwrA (length=549) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

IQELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSY
LYETVPEYIVLDDVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGK
VDNSILKEVNVENYLLECNNIIVKNDEIMKNNTSYFYNLTVVVKTFVNDP
LSMLVVIKYIEELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIH
LEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCL
YNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNIFVE
PKRAVQRMFEMINEGASVIDIGGESSAPFVIPNPKISERDLVVPVLQLFQ
KEWNDIAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLK
KKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIP
RYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMND
KDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQV

3D structure

PDB

6jwr The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	PT1	A	P438 D482 N502 I504 M529 D575 G579 F580 F603 G605 K609 R610 R686	P328 D364 N384 I386 M411 D457 G461 F462 F485 G487 K491 R492 R529
BS02	AMP	A	L181 I211 N312 F315 L316 S317 H320	L154 I171 N210 F213 L214 S215 H218
BS03	MG	A	D208 D210	D168 D170
BS04	PH2	A	T57 E60 F163 N165 R326	T54 E57 F136 N138 R224
BS05	CA	A	E42 G46 E99	E39 G43 E81

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6jwr, PDBe:6jwr, PDBj:6jwr
PDBsum	6jwr
PubMed	31883412
UniProt	Q25704

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