Structure of PDB 6jwq Chain A

Receptor sequence
>6jwqA (length=548) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPEYIDVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNS
ILKEVNVENYLLECNNIIVKNDEIMKNNSYFYNLTVVVKTFVNDPLSMLV
VIKYIEELMKRIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLERD
PQEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRC
LYNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNYEP
KRAVQRMFEMINEGASVIDIGGESKISERDLVVPVLQLFQKEWNDIKNKI
VKCDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKK
NKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRY
RILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMNKDQ
LLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKD
3D structure
PDB6jwq The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D208 D210 D164 D166
BS02 ATP A L181 K185 D208 D210 I211 N312 F315 L316 S317 H320 R326 L149 K153 D164 D166 I167 N211 F214 L215 S216 H219 R225
BS03 CA A E42 G46 K47 E99 E38 G42 K43 E77
Gene Ontology
Molecular Function
GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156 dihydropteroate synthase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0016310 phosphorylation
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005740 mitochondrial envelope

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Cellular Component
External links
PDB RCSB:6jwq, PDBe:6jwq, PDBj:6jwq
PDBsum6jwq
PubMed31883412
UniProtQ25704

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