Structure of PDB 6jwj Chain A

Receptor sequence

>6jwjA (length=466) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

SIKELAVDEELAAADGLIPRQKSKLCKHGDRGMCEYCSPLPPWDKEYHEK
NKIKHISFHSYLKKLNENANKKENGSSYISPLSEPDFRINKRCHNGHEPW
PRGICSKCQPSAITLQQQEFRMVDHVEFQKSEIINEFIQAWRYTGMQRFG
YMYGSYSKYDNTPLGIKAVVEAIYEPPQHDEQDGLTMDVEQVKNEMLQID
RQAQEMGLSRIGLIFTDLSDAGAGDGSVFCKRHKDSFFLSSLEVIMAARH
QTRHPNVSKYSEQGFFSSKFVTCVISGNLEGEIDISSYQVSTEAEALVTA
DMISGSTFPSMAYINDTTDERYVPEIFYMKSNEYGITVKENAKPAFPVDY
LLVTLTHGFPNTTNSKFVSSTGFPWSNRQAMGQSQDYQELKKYLFNVASS
GDFNLLHEKISNFHLLLYINSLQILSPDEWKLLIESAVKNEWEESLLKLV
SSAGWQTLVMILQESG

3D structure

PDB

6jwj Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4.

Chain

Resolution

1.58 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Q258 D294 G295 L296 T297 V300 F326 T327 D328 F340 K342 L353 E354 R364 S415 G416 S417 T418 F419 P420 Y424 N426 P455	Q147 D183 G184 L185 T186 V189 F215 T216 D217 F229 K231 L242 E243 R253 S304 G305 S306 T307 F308 P309 Y313 N315 P344
BS02	ZN	A	C137 H139 C145 C148	C26 H28 C34 C37
BS03	ZN	A	C204 H208 C216 C219	C93 H97 C105 C108

Gene Ontology

	Biological Process
GO:0006511	ubiquitin-dependent protein catabolic process

View graph for
Biological Process

External links

PDB	RCSB:6jwj, PDBe:6jwj, PDBj:6jwj
PDBsum	6jwj
PubMed	31836717
UniProt	P33755\|NPL4_YEAST Nuclear protein localization protein 4 (Gene Name=NPL4)

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