Structure of PDB 6jv2 Chain A

Receptor sequence

>6jv2A (length=3509) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD
LSICTFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHSYSGMYLCCLST
SRKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSE
RYLHLSYLHVDAAFQQTLWSVAPISSAQGYLIGGDVLRLLHGECLTVPSG
EHEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTT
GKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLRKEVDGMGTSEIKY
GDSVCFIQHIGTGLWLTYQSSIQRKAIMHHEGHMDDGLNLSRSQHEESRT
ARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHP
PDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSVAGRE
AGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGI
LEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCH
GVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGKKWYYELMV
DHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDG
LHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMF
ENFNIDGLFFPVVSFSAGIKVRFLLGEFKFLPPPGYAPCYEAVLPKEKLK
VEHSREYKQERTYTRDLLGPTVSAFTPIPVDTSQIVLPPHLERIREKLAE
NIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSL
ETLKTLLALGCHVGISDEHAYQLTSGYKPAPMDLSFIKLTPSQEAMVDKL
AENAHNVWARDRIRQRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYG
YNLEARFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQEL
GSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLN
GEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFT
ICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSSHEHIEVTRIDVTQK
SFGSQNSSTDIMFYRLSMPIECTYYYSVRIFPNVWVGWITSDFHQYDTAF
DLVTVTLGDEKGKVHESIKRSNYMVCANNNGLEIGCVVGLLTFTANGKDL
STYYQVEPSTKLFPAVFAQATSPNVFQFEAGLFKSEHKNPVPQCPPRLHV
QFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLEPLQFMSLHIPEENRS
VDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYA
IENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITL
FPDGLPGIGLSTSLRPRMQFSSPSFVSINNECYQYSPEFPLDILKAKTIQ
MLTEAVQEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHIL
QLIEPSGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAK
LQDNQRFRYNEVMQALNECPCPEEIRDQLLDFHEDLMTHCGIELDLTIRG
RLLSLVEKVTYTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGI
GGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVEEEKLMIRGLGDI
MNNKVFYQHPNLMRALGMHETVMEVMVNVLGPKMVANCCRFLCYFCRISR
QNQKAMFDHLSYLLENSSVTPLDVAAASVMDNNELALALREPDLEKVVRY
LAGCGLPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPEGLLAAM
EEAIKIGNAIMTFYAALIDLLGRCAPEMHLIHAAKGEAIRIRSILRSLIP
LGDLVGVISIAFQFCPDHKAAMVLFLDRVYVQDFLLHLLEVGFLPDLRAA
ASLTDMALALNRYLCTAVLPLLLFAGTEHHASLIDSLLHTVKGCSLTKAQ
RDSIEVCLLSRPSMMQHLLRRLVFDVPLLNKMPLKLLTNHYERCWKYYCL
PGGASEEELHLSRKLFWGIFDALYEQELFKLALPCLSAVAGALPPNFNPQ
PVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQ
PLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDAHGYSPRA
IDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYD
TLTAKEKAKDREKAQDILKFLQINGYAVSRGYFLSAASRPLCSGGHASNK
EKEMVFCKLGVLVRHRISLFGNDATLHILGQTLDARTVMKTGLESVKFLD
NAAEDLEKTMENLKQGQFTTTVALLPMLSSLFEHIGQHQFLEDVQVSCYR
ILTSLYALGTSVERQRSALGECLAAFAGAAFLETHLDKHNIYSKAVWHKL
LSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKL
IEDLAKPRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCSFE
EKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAI
LNGGNSTVQQKMLEYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAE
GLGMVGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTV
NIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFN
TLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELL
KELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFD
MFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLS
CAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTF
LELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKES
KRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQIIAYQQKLLNYFA
RNFYNMRMLALFVAFAINFILLFYKVHYVLEESSGYMEPTLRILAILHTV
ISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWD
RLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGSAVLNSIDVK
YQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLR
TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDM
KCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFV
IVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHG
FETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPA
GDCFRKQYE

3D structure

• PDB: 6jv2 Modulation of cardiac ryanodine receptor 2 by calmodulin.
• Chain: A
• Resolution: 4.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C4889 I4891 C4892 H4914	C3434 I3436 C3437 H3459
BS02	CA	A	E3849 E3923 T4932 E4933	E2730 E2804 T3477 E3478

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Dec 1 19:05:03 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6jv2', asym_id = 'A', title = 'Modulation of cardiac ryanodine receptor 2 by calmodulin.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6jv2', asym_id='A', title='Modulation of cardiac ryanodine receptor 2 by calmodulin.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6jv2', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6jv2', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>