Structure of PDB 6jut Chain A

Receptor sequence
>6jutA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
FVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEIL
SVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHI
MTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF
HNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFK
GLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQII
SILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFK
3D structure
PDB6jut Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D133 R137 N138 D151
Catalytic site (residue number reindexed from 1) D126 R130 N131 D144
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C9O A C22 V30 A43 K45 A54 L57 S58 I66 F68 I80 T82 Y84 A85 V140 C150 D151 F152 G153 C15 V23 A36 K38 A47 L50 S51 I59 F61 I73 T75 Y77 A78 V133 C143 D144 F145 G146 MOAD: ic50=2.1nM
PDBbind-CN: -logKd/Ki=8.68,IC50=2.1nM
BindingDB: IC50=2.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6jut, PDBe:6jut, PDBj:6jut
PDBsum6jut
PubMed31244114
UniProtQ9NYL2|M3K20_HUMAN Mitogen-activated protein kinase kinase kinase 20 (Gene Name=MAP3K20)

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