Structure of PDB 6jtz Chain A

Receptor sequence
>6jtzA (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
NRPNLYYEVRQKPSNTEDFIEDIVKLINGRYKGQSGIIYCFSQKDSEQVT
VSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKP
DVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDIFRISSMVV
MENVGQQKLYEMVSYCQNISKCRRVLMAQHFDEVACNKMCDNCCKDSAFE
RKNITEYCRDLIKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAP
TLPREDLEKIIAHFLIQQYLKEDYSAAISYLKIGPKANLLNNEAHAITMQ
VTK
3D structure
PDB6jtz Residues at the interface between zinc binding and winged helix domains of human RECQ1 play a significant role in DNA strand annealing activity.
ChainA
Resolution2.797 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C453 C471 C475 C478 C172 C186 C190 C193
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:6jtz, PDBe:6jtz, PDBj:6jtz
PDBsum6jtz
PubMed34751402
UniProtP46063|RECQ1_HUMAN ATP-dependent DNA helicase Q1 (Gene Name=RECQL)

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