Structure of PDB 6jtg Chain A

Receptor sequence
>6jtgA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
SLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQAR
IFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHE
IELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAP
DTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT
IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESI
EAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQ
QADSFKATRFNLEVREIQEKLDAFIEALHQ
3D structure
PDB6jtg Structural insights into G domain dimerization and pathogenic mutation of OPA1.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A S36 G38 K39 T40 S41 R54 G55 S56 K206 D208 L209 V240 T241 G242 K243 S36 G38 K39 T40 S41 R54 G55 S56 K206 D208 L209 V240 T241 G242 K243
BS02 MG A T40 T61 T40 T61
BS03 BEF A S36 K39 M60 T61 G139 S36 K39 M60 T61 G139
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6jtg, PDBe:6jtg, PDBj:6jtg
PDBsum6jtg
PubMed32379273
UniProtO60313|OPA1_HUMAN Dynamin-like GTPase OPA1, mitochondrial (Gene Name=OPA1)

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