Structure of PDB 6jt9 Chain A

Receptor sequence

>6jt9A (length=1286) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium)

GSGLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHF
ADLNAPLNDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSK
ATDIAHNCGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVF
SSLTDAEKLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYL
QEAFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKM
IKNTFETTPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHIL
MKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNL
RIPGFEQPWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFR
TYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLG
GPAMNIGFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLS
NAMPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQ
LPLFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKT
PKMTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFLVTIGDRT
VTGMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAPVALLDFA
ASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYDAVKA
VGEELCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFARVE
DVRHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDKPADVRD
VAQLKGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQVDI
AALGDDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQAL
AGDRFVITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHEAK
ANDTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNSHVEMAAA
FHRAGFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGAGEGWAKS
ILFNHRVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSELWPRFVR
NHSDRFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDAHL
AALESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENGRVTIMMP
HPERVFRTVANSWHPENWGEDSPWMRIFRNARKQLG

3D structure

• PDB: 6jt9 Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation.
• Chain: A
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 6.3.5.3: phosphoribosylformylglycinamidine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	D679 N722 D884	D670 N713 D875
BS02	ADP	A	T386 G387 Y388 K649 L652 Q668 P676 A678 N722	T396 G397 Y398 K640 L643 Q659 P667 A669 N713

Gene Ontology

Molecular Function

• GO:0004642 phosphoribosylformylglycinamidine synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006189 'de novo' IMP biosynthetic process
• GO:0006541 glutamine metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6jt9, PDBe:6jt9, PDBj:6jt9
• PDBsum: 6jt9
• PubMed: 32284973
• UniProt: P74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)