Structure of PDB 6jt8 Chain A

Receptor sequence

>6jt8A (length=1288) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium)

GLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHFAD
LNAPLNDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSKAT
DIAHNCGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVFSS
LTDAEKLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYLQE
AFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKMIK
NTFETTPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHILMK
VETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRI
PGFEQPWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTY
EEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLGGP
AMNIGLGLDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGG
LSNAMPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAA
DQLPLFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLG
KTPKMTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFLVTIGD
RTVTGMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAPVALLD
FAASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYDAV
KAVGEELCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFAR
VEDVRHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDKPADV
RDVAQLKGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQV
DIAALGDDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQ
ALAGDRFVITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHE
AKANDTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNSHVEMA
AAFHRAGFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGAGEGWA
KSILFNHRVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSELWPRF
VRNHSDRFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDA
HLAALESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENGRVTIM
MPHPERVFRTVANSWHPENWGEDSPWMRIFRNARKQLG

3D structure

• PDB: 6jt8 Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation.
• Chain: A
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 6.3.5.3: phosphoribosylformylglycinamidine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	T386 G387 Y388 K649 L652 Q668 P676 A678 N722	T394 G395 Y396 K642 L645 Q661 P669 A671 N715
BS02	MG	A	D679 N722 D884	D672 N715 D877

Gene Ontology

Molecular Function

• GO:0004642 phosphoribosylformylglycinamidine synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006189 'de novo' IMP biosynthetic process
• GO:0006541 glutamine metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6jt8, PDBe:6jt8, PDBj:6jt8
• PDBsum: 6jt8
• PubMed: 32284973
• UniProt: P74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)