Structure of PDB 6jt7 Chain A

Receptor sequence

>6jt7A (length=1282) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium)

GSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHFADLNAPL
NDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSKATDIAHN
CGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVFSSLTDAE
KLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYLQEAFTKL
GRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKMIKNTFET
TPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHILMKVETHN
HPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQ
PWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTYEEKVN
SHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLGGPAMNIG
LLDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLSNAMP
ELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQLPLF
DELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKTPKMT
RDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFLVTIGDRTVTGM
VARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAPVALLDFAASAR
LAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYDAVKAVGEE
LCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFARVEDVRH
TLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDKPADVRDVAQL
KGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQVDIAALG
DDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQALAGDR
FVITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHEAKANDT
DPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNSHVEMAAAFHRA
GFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGAGEGWAKSILFN
HRVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSELWPRFVRNHSD
RFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDAHLAALE
SKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENGRVTIMMPHPER
VFRTVANSWHPENWGEDSPWMRIFRNARKQLG

3D structure

• PDB: 6jt7 Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation.
• Chain: A
• Resolution: 1.86 Å

Enzymatic activity

• Enzyme Commision number: 6.3.5.3: phosphoribosylformylglycinamidine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	V333 T386 G387 Y388 K649 L652 Q668 P676 A678 N722	V336 T389 G390 Y391 K636 L639 Q655 P663 A665 N709
BS02	MG	A	D679 N722 D884	D666 N709 D871

Gene Ontology

Molecular Function

• GO:0004642 phosphoribosylformylglycinamidine synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006189 'de novo' IMP biosynthetic process
• GO:0006541 glutamine metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6jt7, PDBe:6jt7, PDBj:6jt7
• PDBsum: 6jt7
• PubMed: 32284973
• UniProt: P74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)