Structure of PDB 6jt2 Chain A

Receptor sequence
>6jt2A (length=506) Species: 9606 (Homo sapiens) [Search protein sequence]
SRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKFEKTIAEQAVAAGVP
VEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQASILCL
LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLYLLYSVHSLVIPTS
LFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDKPNFEEYFEILTPKINQ
TFSGIMTMLNMQFVVRVRRVMDLKGQMIYIVESSAILFLGSPCVLYLSDI
PIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDL
LCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVI
TMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA
VKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTL
ANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGI
CHFLDA
3D structure
PDB6jt2 Structural insights into the mechanism of human soluble guanylate cyclase.
ChainA
Resolution3.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D486 I487 D530
Catalytic site (residue number reindexed from 1) D333 I334 D377
Enzyme Commision number 4.6.1.2: guanylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G2P A D486 I487 V488 G489 F490 T491 G529 D530 R574 D333 I334 V335 G336 F337 T338 G376 D377 R421
BS02 MG A D486 I487 D530 D333 I334 D377
BS03 MG A D486 D530 D333 D377
Gene Ontology
Molecular Function
GO:0004383 guanylate cyclase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016829 lyase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0020037 heme binding
GO:0038023 signaling receptor activity
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0007263 nitric oxide mediated signal transduction
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0009190 cyclic nucleotide biosynthetic process
GO:0010750 positive regulation of nitric oxide mediated signal transduction
GO:0019934 cGMP-mediated signaling
GO:0035556 intracellular signal transduction
GO:0038060 nitric oxide-cGMP-mediated signaling
GO:0060087 relaxation of vascular associated smooth muscle
GO:0070482 response to oxygen levels
GO:0098925 retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008074 guanylate cyclase complex, soluble
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jt2, PDBe:6jt2, PDBj:6jt2
PDBsum6jt2
PubMed31514202
UniProtQ02108|GCYA1_HUMAN Guanylate cyclase soluble subunit alpha-1 (Gene Name=GUCY1A1)

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