Structure of PDB 6jpn Chain A

Receptor sequence

>6jpnA (length=770) Species: 1473580 (Defluviitalea phaphyphila)

ANYETYDGFKVSEEPVLPEKEVHPSLWFTKSDIQKIKEKKNEDSFTAELW
EEISNSPYLTMEIPTDIPSATDSDTDIHKYYGNMSRIAKYNAFMYLMTGK
SEYRLRATEALKRAFDGPIYEMDPTVSGSGVDEIYRAVWAQNFATAYDWI
QPYLSDEDDEIIRERLAKEAQVVYENLYTWGPRPHNALSKPAWGLGTLAL
TLSDHPDASKWLNRALEAANTNTLYFFNKDGHYREGAHYYVYSLVNLIPF
LYHYKNVSGVNYFPEYKNIFEWAVKIRNGRGWMPNVEDSWIKPAPTHMVA
SQYKDTDTDLHSTAKLANILQWSYFNTDFRPWEPDGSYTGASYDDTWDID
QYLTYDSTIEQIKPDVSGTVFMNNSGQTVFRSDWNFNNPNSRYLLFQGVA
EADNHYHYDHLSFIIHAENQMMASDSGYSRNSYGEGIRTSWYLTAEAHNV
ITANGEHPKDVSENTTPVSRYDMDTDFFDFQEKEAVYDGFTFPEKNSYDF
SGKQIRAIGFPRQDYFVVADQLFSDKEVQYDLYLHGGRGEMSGEGNYRLW
TYEDDRYGQEAKMAAWVFPSKESIFIDKEGEVNYEAGAFNSYGYLNARQI
AKDTMFMQIIVPLSKYADIPEVVDLSTDDVVGGTVVKDNEKDTFMQQLNN
AENSLGDITTDATFAYTNENSNNELQHFSVRQGTSLDYKGENIFVSNKPI
TFALDISDETQYKGTIAALNETVELRVKNPVGVPTESVVVNGENIEFSVE
DGYTVIQVAEGGDININFGE

3D structure

• PDB: 6jpn The molecular basis of endolytic activity of a multidomain alginate lyase fromDefluviitalea phaphyphila, a representative of a new lyase family, PL39.
• Chain: A
• Resolution: 2.85 Å

Enzymatic activity

• Enzyme Commision number: 4.2.2.3: mannuronate-specific alginate lyase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BEM	A	P182 R183 H185	P182 R183 H185
BS02	BEM	A	S127 N404 Y433	S127 N404 Y433
BS03	BEM	A	N186 Y239 H405	N186 Y239 H405
BS04	BEM	A	H238 Y239 G340	H238 Y239 G340
BS05	BEM	A	G340 S342	G340 S342
BS06	MN	A	H407 D425 G427 H448	H407 D425 G427 H448
BS07	CA	A	E287 E401 H407 D409	E287 E401 H407 D409
BS08	CA	A	T369 D474 T475 D479 Q513	T369 D474 T475 D479 Q513
BS09	MG	A	P124 D132 E133	P124 D132 E133

Gene Ontology

Molecular Function

• GO:0016829 lyase activity

External links

• PDB: RCSB:6jpn, PDBe:6jpn, PDBj:6jpn
• PDBsum: 6jpn
• PubMed: 31624143
• UniProt: A0A4Y5UXE1