Structure of PDB 6jmf Chain A

Receptor sequence
>6jmfA (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]
EVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDG
LPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAV
PKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPD
LKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR
TEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKI
SDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGIL
LWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY
EPGQRPSFSTIYQELQSIRKRH
3D structure
PDB6jmf Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D683 R687 N688 D701
Catalytic site (residue number reindexed from 1) D234 R238 N239 D252
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9FC A I567 A588 K590 M636 E637 L638 V639 G642 R687 L690 S700 D701 I118 A139 K141 M187 E188 L189 V190 G193 R238 L241 S251 D252
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6jmf, PDBe:6jmf, PDBj:6jmf
PDBsum6jmf
PubMed31097992
UniProtP07332|FES_HUMAN Tyrosine-protein kinase Fes/Fps (Gene Name=FES)

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