Structure of PDB 6jk8 Chain A

Receptor sequence
>6jk8A (length=823) Species: 9606 (Homo sapiens) [Search protein sequence]
EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISRSYRFPKLTVITEYL
LLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRN
ITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPCE
KTTINNEYNYRCWTTNRCQKMCPSTCACTENNECCHPECLGSCSAPDNDT
ACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGF
VIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTS
AQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHAL
VSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKM
YFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFT
STTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGS
NSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRG
AKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIV
RWQRQPQDGYLYRHNYCSKDKIPIRKYAGPCCACPKTEAEKQAEKEEAEY
RKVFENFLHNSIFVPRPYPFFESRVDNKERTVISNLRPFTLYRIDIHSCN
HEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPEN
PNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQA
TSLSGNGSWTDPVFFYVQAKTGY
3D structure
PDB6jk8 Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis.
ChainA
Resolution5.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V733 P734 R735 P736 V664 P665 R666 P667
BS02 peptide A D38 R40 K721 R735 D8 R10 K652 R666
BS03 MAN A T498 T500 T452 T454
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jk8, PDBe:6jk8, PDBj:6jk8
PDBsum6jk8
PubMed32275863
UniProtP08069|IGF1R_HUMAN Insulin-like growth factor 1 receptor (Gene Name=IGF1R)

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