Structure of PDB 6jio Chain A

Receptor sequence
>6jioA (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
VQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPSASQQRFAHFTELA
IISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETE
CITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIA
INIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKL
VSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHKILHRLLQD
3D structure
PDB6jio Identify liver X receptor beta modulator building blocks by developing a fluorescence polarization-based competition assay.
ChainA
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BQ3 A L274 A275 M312 F329 H435 L49 A50 M87 F104 H210 PDBbind-CN: -logKd/Ki=4.55,Ki=28uM
BindingDB: Ki=28000nM,EC50=57000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6jio, PDBe:6jio, PDBj:6jio
PDBsum6jio
PubMed31202993
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

[Back to BioLiP]