Structure of PDB 6jim Chain A

Receptor sequence

>6jimA (length=454) Species: 37124 (Chikungunya virus)

GIIETPRGAIKVTAQPTDHVVGEYLVLSPQTVLRSQKLSLIHALAEQVKT
CTHNGYDGRVLVPSGYAISPEDFQSLSESATMVYNEREFVNRKLHHIAMH
GPALNTDEESYELVRAERTEHEYVYDVDQRRCCKKEEAAGLVLVGDLTNP
PYHEFAYEGLKIRPACPYKIAVIGVFGVPGSGKSAIIKNLVTRQDLVTSG
KKENCQEITTDVMRQRGLEISARTVDSLLLNGCNRPVDVLYVDEAFACHS
GTLLALIALVRPRQKVVLCGDPKQCGFFNMMQMKVNYNHNICTQVYHKSI
SRRCTLPVTAIVSSLHYEGKMRTTNEYNKPIVVDTTGSTKPDPGDLVLTC
FRGWVKQLQIDYRGYEVMTAAASQGLTRKGVYAVRQKVNENPLYASTSEH
VNVLLTRTEGKLVWKTLSGDPWIKTLQNPPKGNFKATIKEWEVEHASIMA
GICS

3D structure

• PDB: 6jim Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.19: polynucleotide adenylyltransferase.
  3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.1.74: mRNA 5'-phosphatase.
  3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Y132 Y161 F164 K210 K211 T233 D235 S236 N240 F287 F360 R361 G362 K365 T378 A380 N400 L402 H409	Y123 Y152 F155 K201 K202 T224 D226 S227 N231 F278 F351 R352 G353 K356 T369 A371 N391 L393 H400
BS02	ADP	A	G189 G191 K192 S193 A194 R311 R312 T386 W450	G180 G182 K183 S184 A185 R302 R303 T377 W441

Gene Ontology

Molecular Function

• GO:0005524 ATP binding

External links

• PDB: RCSB:6jim, PDBe:6jim, PDBj:6jim
• PDBsum: 6jim
• PubMed: 31000599
• UniProt: A0A076V769