Structure of PDB 6jfm Chain A

Receptor sequence
>6jfmA (length=419) Species: 9606 (Homo sapiens) [Search protein sequence]
NASPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEEQ
VLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSDVINAMLWDKVLPS
GITNCFLRVEGTDGHEAFLLTEGSEEKRSAKTVNQLAHALHQDKQLHAGS
LVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVA
NSESTLMQTEKHFFHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQH
MERCTSFLVDELGVVDRSQAGDRIFFVSAKEVLNARIQKAQGMPELAEGF
QVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHM
AAREQQVYCEEMREERQDRTRENLEQEIAAMNKKIEVLDSLQSKAKLLRN
KAGWLDSELNMFTHQYLQP
3D structure
PDB6jfm Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A R384 E391 R353 E360
BS02 CA A E73 D77 E49 D53
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0008053 mitochondrial fusion
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jfm, PDBe:6jfm, PDBj:6jfm
PDBsum6jfm
PubMed31664033
UniProtO95140|MFN2_HUMAN Mitofusin-2 (Gene Name=MFN2)

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