Structure of PDB 6jey Chain A

Receptor sequence
>6jeyA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTDKSPFVIYDMNSLMM
GEDKIKKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL
KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKF
EFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALE
LQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPL
LQEIYKD
3D structure
PDB6jey Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EJL A P227 L228 R288 S289 E295 I326 M329 L333 I341 S342 E343 P21 L22 R70 S71 E77 I108 M111 L115 I123 S124 E125
BS02 EJL A I281 F282 G284 C285 Q286 R288 V339 I341 M348 L353 F363 M364 H449 I63 F64 G66 C67 Q68 R70 V121 I123 M130 L135 F145 M146 H231
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6jey, PDBe:6jey, PDBj:6jey
PDBsum6jey
PubMed31991094
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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